瞿昌华

时间：2021-08-26 16:23:43 来源：作者：

::个人资料::

姓名：瞿昌华

性别：男

最高学位：博士学位

职称：副主任医师

职务：神经内科牵头副主任、神经内I科主任

E-mail ： 546473062@qq.com

研究方向：脑血管疾病、痴呆与认知障碍

::个人简介：::

瞿昌华，神经病学博士, 神经内科、神经内I科牵头副主任，硕士研究生导师。湖北民族大学神经精神病学教研室主任，神经内科住院医师培训基地主任，湖北省脑血管病防治学会神经重症专业委员会常务委员。

主要从事脑血管病的介入诊断和治疗，包括急性脑血管闭塞介入取栓、急性脑梗死超早期静脉溶栓、动脉溶栓、脑血管狭窄支架成形术、脑血管闭塞介入开通术等临床和科研工作。擅长脑血管疾病及介入、痴呆与认知障碍、反复头痛头晕、周围神经病、颅内感染性疾病、癫痫及神经系统疑难病的诊断和治疗。

近年来获批省部级课题1项，主持完成地厅级课题2项。发表论文10余篇，其中SCI收录5篇。

::承担的研究项目及经费：::

血管内皮 Caveolin-1 蛋白在血管性认知损害大鼠血脑屏障损伤及认知功能障碍中的作用及机制研究（8万元）

::公开发表论文、教材及专著：::

1: Qu C, Xu L, Shen J, Li Y, Qu C, Song H, Zhang J. Protection of blood-brain barrier as a potential mechanism for enriched environments to improve cognitive impairment caused by chronic cerebral hypoperfusion. Behav Brain Res. 2020 Feb3;379:112385. doi: 10.1016/j.bbr.2019.112385. Epub 2019 Nov 25. PMID: 31778736.

2: Qu C, Song H, Shen J, Xu L, Li Y, Qu C, Li T, Zhang J. Mfsd2a Reverses Spatial Learning and Memory Impairment Caused by Chronic Cerebral Hypoperfusion via Protection of the Blood-Brain Barrier. Front Neurosci. 2020 Jun 16;14:461.doi: 10.3389/fnins.2020.00461. PMID: 32612494; PMCID: PMC7308492.

3: Qu C, Qu C, Xu L, Shen J, Lv D, Li Y, Song H, Li T, Zheng J, Zhang J. Nuclear receptor TLX may be through regulating the SIRT1/NF-κB pathway to ameliorate cognitive impairment in chronic cerebral hypoperfusion. Brain Res Bull. 2021 Jan;166:142-149. doi: 10.1016/j.brainresbull.2020.11.006. Epub 2020 Nov 13.

PMID: 33197535.

4: Lu X, Li C, Qu C, Huang J, Wang Q, Qiu B, Wang C, Li S, Xu H, Liu Y. A High Resolution MRI Study of the Relationship

Between Plaque Enhancement and Perforator Stroke after Stenting for Symptomatic Vertebrobasilar Artery

Stenosis. J Stroke Cerebrovasc Dis. 2021 Mar;30(3):105558. doi:10.1016/j.jstrokecerebrovasdis.2020.105558. Epub 2020 Dec 18. PMID: 33348247.

5:Xu L, Qu C, Qu C, Shen J, Song H, Li Y, Li T, Zheng J, Zhang J. Improvement of autophagy dysfunction as a potential mechanism for environmental enrichment to protect blood-brain barrier in rats with vascular cognitive impairment.

Neurosci Lett. 2020 Nov 20;739:135437. doi: 10.1016/j.neulet.2020.135437. Epub 2020 Oct 22. PMID: 33132180.

6: Yan N, Xu Z, Qu C, Zhang J. Dimethyl fumarate improves cognitive deficits in chronic cerebral hypoperfusion rats by alleviating inflammation, oxidative stress, and ferroptosis via NRF2/ARE/NF-κB signal pathway. Int Immunopharmacol.2021 Sep;98:107844. doi: 10.1016/j.intimp.2021.107844. Epub 2021 Jun 18. PMID:34153667.

::课程建设：::